Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4502848 | Theoretical Population Biology | 2010 | 7 Pages |
Abstract
Feldman and Karlin conjectured that the number of isolated fixed points for deterministic models of viability selection and recombination among n possible haplotypes has an upper bound of 2nâ1. Here a proof is provided. The upper bound of 3nâ1 obtained by Lyubich et al. (2001) using Bézout's Theorem (1779) is reduced here to 2n through a change of representation that reduces the third-order polynomials to second order. A further reduction to 2nâ1 is obtained using the homogeneous representation of the system, which yields always one solution 'at infinity'. While the original conjecture was made for systems of selection and recombination, the results here generalize to viability selection with any arbitrary system of bi-parental transmission, which includes recombination and mutation as special cases. An example is constructed of a mutation-selection system that has 2nâ1 fixed points given any n, which shows that 2nâ1 is the sharpest possible upper bound that can be found for the general space of selection and transmission coefficients.
Related Topics
Life Sciences
Agricultural and Biological Sciences
Agricultural and Biological Sciences (General)
Authors
Lee Altenberg,