| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4514580 | Industrial Crops and Products | 2011 | 4 Pages |
Antioxidant, antibacterial and antiviral effects of aqueous and methanol extracts of Lactuca sativa var longifolia leaves were investigated. The antioxidant activity was evaluated using the DPPH assay. The effect of the extracts against 5 Gram-positive and 6 Gram-negative bacteria was tested. The antiviral activity was determined against human cytomegalovirus (HCMV) strain AD-169 (ATCC Ref. VR 538) and coxsackie B virus type 3 (CoxB-3) using a cytopathic effect (CPE) reduction assay. The methanol extract had the highest total phenolic contents (235.31 mg CE/g extract). It exhibited a significantly (p < 0.05) greater hydroxyl radical-scavenging activity (IC50 = 3.5 μg/ml) than the aqueous extract (4.1 μg/ml). It was also the most effective extract with the lowest MIC (2.5 mg/ml) against all Gram negative and Gram positive bacteria. Methanol and aqueous extracts exhibited antiviral activity against HCMV and Cox-B3 viruses with IC50 of 200 μg/ml.
► We investigated the antioxidant, antibacterial and antiviral effects of Lactuca sativa var longifolia leaves extracts. ► Methanol extract exhibited a significantly greater hydroxyl radical-scavenging activity. ► Methanol extract was the most effective extract against all Gram positive and Gram negative tested bacteria. ► Methanol and aqueous extracts exhibited antiviral activity against HCMV and Cox-B3 viruses.
