| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4520467 | South African Journal of Botany | 2015 | 6 Pages |
•Achillea was evaluated to ascertain medicinal claims for its efficacy in Egyptian folk medicine.•Achillea exhibited anti-inflammatory activity in a rat model of carrageenan-induced paw edema.•The extracts exhibited analgesic activity that was explored using hot plate and writhing tests.•The extracts revealed protective effects against rat ulcerative colitis and gastric ulcers.
Achillea fragrantissima is a perennial herb grown in Egypt and traditionally employed medicinally for its anti-inflammatory and analgesic properties among Sinai inhabitants. Non-polar and polar extracts were obtained by successive foliar extraction with dichloromethane:methanol (1:1) and 70% aqueous methanol, respectively. Achillea extracts were assayed in rodents for anti-inflammatory, anti-ulcerogenic and analgesic activities.Materials and methodsAcute toxicity of non-polar and polar extracts of A. fragrantissima was evaluated in mice. Anti-inflammatory activity was assessed in carrageenan-induced rat-paw edema test while analgesic activity was explored centrally and peripherally using hot plate and writhing tests, respectively. In addition, anti-ulcerogenic activity was assayed in colon and gastric tissues.ResultsFoliar extracts of A. fragrantissima exhibited anti-inflammatory, central and peripheral analgesic activities. Moreover, both non-polar and polar fractions revealed protective effects against rat ulcerative colitis and gastric ulcers.ConclusionA. fragrantissima extracts possess anti-inflammatory, central and peripheral analgesic activities in addition to protective properties in colonic and gastric tissues.
