| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4531252 | Aquatic Toxicology | 2006 | 10 Pages |
Abstract
The present findings indicate that chemical impurities of the commercial PeBDE product account for AhR-mediated effects. Analytical isolation of a planar fraction from the commercial product increased the in vitro (DR-CALUX) signal 10 times. Immunohistochemistry showed a strong tissue specific reaction to DE-71 in vivo at these relatively low TEQ levels regardless of chemical pretreatment of the mix, reflecting the sensitivity of CYP1A induction in juvenile zebrafish to AhR agonists.
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Authors
R.V. Kuiper, A.J. Murk, P.E.G. Leonards, G.C.M. Grinwis, M. van den Berg, J.G. Vos,