Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4546298 | Harmful Algae | 2006 | 6 Pages |
Abstract
Synthetic azaspiracid-1 (AZA-1, 1), 6-, 10-, 13-, 14-, 16-, 17-, 19-, 20-epi-azaspiracid-1 (C1–C20-epi-AZA-1, 2), and twelve truncated azaspiracid-1 analogs (3–14) were synthesized and tested for their toxicity effects in mice. Of these compounds only AZA-1 (1) and its diastereomer C1–C20-epi-AZA-1 (2) exhibited significant toxicity in mice with the latter compound (2) being one-fourth as toxic as the former (1). The lack of toxicity exhibited by the severely truncated analogs (3–14) implies that the entire or at least a major part of the structure of AZA-1 (1) is required for biological activity.
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Authors
Emiko Ito, Michael O. Frederick, Theocharis V. Koftis, Wenjun Tang, Goran Petrovic, Taotao Ling, K.C. Nicolaou,