Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5044888 | Evolution and Human Behavior | 2016 | 14 Pages |
This paper empirically investigates the evolutionary drivers of between-population variation of the human DRD4 exon III locus, a particular gene associated with the human personality trait of novelty-seeking behavior. Providing a novel compilation of worldwide DRD4 exon III allele frequencies in a large sample of indigenous populations around the world, this study employs population-specific biogeographic indicators to test the hypothesis of natural selection acting on the set of DRD4 exon III allele variants. The estimates suggest that migratory distance from East Africa and various population-specific biogeographic indicators, such as latitude, land suitability for agriculture, pasture land, and terrain ruggedness, contributed significantly to overall between-population DRD4 exon III polymorphism.