| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5155334 | Bioorganic & Medicinal Chemistry Letters | 2017 | 7 Pages |
Keywords
DCMOATPtPSAHLMDLMppbCLPADMEIC50CLURLMdimethylacetamideDMACDMFUnbound clearanceSARTHF(2,2,6,6-tetramethylpiperidin-1-yl)oxylDMSORat hepatocytesSNArt1/2VSsPlasma protein bindingLipophilic efficiencyTetrahydrofurantrimethylaminePlasma clearanceFraction unboundNucleophilic aromatic substitutionabsorption, distribution, metabolism and excretionapparent volume of distribution at steady stateIntravenousPaindimethylformamideDichloromethaneDimethyl sulfoxideStructure activity relationshipTEMPOTopological polar surface areaPharmacokineticsBioavailabilityLIPEdog liver microsomesRat liver microsomesHuman Liver Microsomeshalf-maximum inhibitory concentrationHalf-lifeHuman hepatocytesVoltage-gatedIntrinsic clearanceorganic anion-transporting polypeptidepolyethylene glycolPEGTEAIon channelClint
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
R. Ian Storer, Andy Pike, Nigel A. Swain, Aristos J. Alexandrou, Bruce M. Bechle, David C. Blakemore, Alan D. Brown, Neil A. Castle, Matthew S. Corbett, Neil J. Flanagan, David Fengas, M. Scott Johnson, Lyn H. Jones, Brian E. Marron, C. Elizabeth Payne,