Discovery of orally bioavailable cyclohexanol-based NR2B-selective NMDA receptor antagonists with analgesic activity utilizing a scaffold hopping approach

Article ID	Journal	Published Year	Pages	File Type
5155410	Bioorganic & Medicinal Chemistry Letters	2017	15 Pages	PDF

Keywords

SAR IBX AcOEt HOBt HERG NCS TBAF DMAP DMF 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride 1-hydroxybenzotriazole N,N-dimethylformamide NMDA receptor antagonist Ethyl acetate o-Iodoxybenzoic acid Scaffold hopping LDA Bioisosteric replacement Structure activity relationship analgesic activity Lithium diisopropylamide human Ether-a-go-go Related Gene Chloramine-T

Related Topics

Physical Sciences and Engineering Chemistry Organic Chemistry

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Discovery of orally bioavailable cyclohexanol-based NR2B-selective NMDA receptor antagonists with analgesic activity utilizing a scaffold hopping approach

Authors

Kosuke Anan, Moriyasu Masui, Shinichiro Hara, Miho Ohara, Masaharu Kume, Shoichi Yamamoto, Shunji Shinohara, Hiroki Tsuji, Shinji Shimada, Shigenori Yagi, Nobuyoshi Hasebe, Hiroyuki Kai,