| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5155570 | Bioorganic & Medicinal Chemistry Letters | 2016 | 7 Pages |
Abstract
New phenylpiperazine derivatives were synthesized and evaluated for binding to adrenergic receptors, α1-adrenolytic properties in vitro and hypotensive activity in vivo. 1-[4-(2,6-dimethylphenoxy)butyl]-4-(2-methoxyphenyl)piperazine hydrochloride possessed the most beneficial pharmacological profile. Structure-activity relationship for the tested compounds was discussed.56
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Authors
Anna Maria Waszkielewicz, Monika Kubacka, Katarzyna PaÅczyk, Szczepan Mogilski, Agata Siwek, Monika GÅuch-Lutwin, Anna GryboÅ, Barbara Filipek,