Synthesis of novel steroidal agonists, partial agonists, and antagonists for the glucocorticoid receptor

Article ID	Journal	Published Year	Pages	File Type
5155625	Bioorganic & Medicinal Chemistry Letters	2017	7 Pages	PDF

Keywords

NF-κB LPS IL-6 PDK4 DIEA DEX qPCR LBD DPPP AF-2 AF-1 FKBP5 GRE AP-1 MMTV 1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate 1,3-bis(diphenylphosphino)propane N,N-diisopropylethylamine Antagonist Agonist Partial agonist interleukin-6 activation function-1 activation function-2 ligand-binding domain Dexamethasone glucocorticoid-response element Nuclear factor-kappa B lipopolysaccharide HATU quantitative real time polymerase chain reaction Mouse mammary tumor virus activator protein 1 glucocorticoid receptor

Related Topics

Physical Sciences and Engineering Chemistry Organic Chemistry

Synthesis of novel steroidal agonists, partial agonists, and antagonists for the glucocorticoid receptor

Authors

Zhuang Jin, Hua Lin, Sathish Srinivasan, Jerome C. Nwachukwu, Nelson Bruno, Patrick R. Griffin, Kendall W. Nettles, Theodore M. Kamenecka,