Variation of the aryl substituent on the piperazine ring within the 4-(piperazin-1-yl)-2,6-di(pyrrolidin-1-yl)pyrimidine scaffold unveils potent, non-competitive inhibitors of the inflammatory caspases

Article ID	Journal	Published Year	Pages	File Type
5155648	Bioorganic & Medicinal Chemistry Letters	2016	5 Pages	PDF

Keywords

caspase-1 Inflammasome inflammation Caspase-5 Caspase-4

Related Topics

Physical Sciences and Engineering Chemistry Organic Chemistry

Preview

Variation of the aryl substituent on the piperazine ring within the 4-(piperazin-1-yl)-2,6-di(pyrrolidin-1-yl)pyrimidine scaffold unveils potent, non-competitive inhibitors of the inflammatory caspases

Authors

Courtney R. Kent, Magdalena Bryja, Helen A. Gustafson, Margaret Y. Kawarski, Gena Lenti, Emily N. Pierce, Rachel C. Knopp, Victor Ceja, Bhabna Pati, D. Eric Walters, Caitlin E. Karver,