| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5155680 | Bioorganic & Medicinal Chemistry Letters | 2016 | 4 Pages |
Abstract
Synthesis of several 7-hydroxy oxysterols and their potential roles as signaling molecules in the innate and adaptive immune responses is discussed. Discovery of a new, fluorinated, synthetic analog of the 7α,25-dihydroxycholesterol-the endogenous ligand of GPR 183 (EBI2), a G-protein coupled receptor highly expressed upon Epstein-Barr virus infection is described. Fluoro oxysterol 12 showed good metabolic stability while maintaining excellent EBI2 agonist activity.88
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Authors
Xiaohu Deng, Siquan Sun, Jiejun Wu, Chester Kuei, Victory Joseph, Changlu Liu, Neelakandha S. Mani,