Synthesis and evaluation of 5-(arylthio)-9H-pyrimido[4,5-b]indole-2,4-diamines as receptor tyrosine kinase and thymidylate synthase inhibitors and as antitumor agents

Article ID	Journal	Published Year	Pages	File Type
5157081	Bioorganic & Medicinal Chemistry Letters	2017	22 Pages	PDF

Keywords

RTX PMX Raltitrexed N-methyl-2-pyrrolidone Colony stimulating factor 1 receptor TGI FLT-3 CSF-1R NMP RTK PDGFR MTX c-kit EGFR DMF 5-FU HTS THF TLC Tetrahydrofuran dimethyl formamide CAM Antiangiogenic agents chorioallantoic membrane Vascular endothelial growth factor Vascular Endothelial Growth Factor (VEGF)5-fluorouracil FMS-like tyrosine kinase 3 Methotrexate total growth inhibition Thymidylate synthase inhibitors platelet derived growth factor receptor Pemetrexed thin layer chromatography receptor tyrosine kinases Epidermal growth factor receptor

Related Topics

Physical Sciences and Engineering Chemistry Organic Chemistry

Synthesis and evaluation of 5-(arylthio)-9H-pyrimido[4,5-b]indole-2,4-diamines as receptor tyrosine kinase and thymidylate synthase inhibitors and as antitumor agents

Authors

Nilesh Zaware, Roy Kisliuk, Anja Bastian, Michael A. Ihnat, Aleem Gangjee,