Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5507239 | Biochimica et Biophysica Acta (BBA) - Bioenergetics | 2017 | 17 Pages |
Abstract
Altered metabolism in cancer cells is pivotal for tumor growth, most notably by providing energy, reducing equivalents and building blocks while several metabolites exert a signaling function promoting tumor growth and progression. A cancer tissue cannot be simply reduced to a bulk of proliferating cells. Tumors are indeed complex and dynamic structures where single cells can heterogeneously perform various biological activities with different metabolic requirements. Because tumors are composed of different types of cells with metabolic activities affected by different spatial and temporal contexts, it is important to address metabolism taking into account cellular and biological heterogeneity. In this review, we describe this heterogeneity also in metabolic fluxes, thus showing the relative contribution of different metabolic activities to tumor progression according to the cellular context. This article is part of a Special Issue entitled Mitochondria in Cancer, edited by Giuseppe Gasparre, Rodrigue Rossignol and Pierre Sonveaux.
Keywords
PHDFASOXPHOSGAPDHFBPFAKRhoAPHEcox2CICIFN-γARG1HMGB1Bcl2VDACmTORC1HUVECTIGARATP citrate lyaseTP53-induced glycolysis and apoptosis regulatorSCO2SASPDEC1TSC2ZEBHK2SGK-1Cancer-Initiating CellRedd1Prolylhydroxylasezinc finger E-box-binding homeoboxMEFPHIFDG-PETCAFCREBCSCAMPKHIF-1PPPExtracellular pHIntracellular pHras homolog gene family, member AROSadenosine monophosphate kinasePancreatic ductal adenocarcinomaPDAC یا pancreatic ductal adenocarcinomaBranched-chain amino acidfatty acid synthaseMRIBCAATAMMagnetic resonance imagingEMThigh-mobility group box 1ACLCancerNSCLCNon-small cell lung cancerHuman umbilical vein endothelial cellcancer stem cellcytochrome oxidaseVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)fructose 1,6-bisphosphateOxidative phosphorylationSenescence-associated secretory phenotypemurine embryonic fibroblastcancer-associated fibroblastlactate dehydrogenaseLDHB-cell lymphoma 2Tumor-associated macrophageMetabolismMetastasismesenchymal to epithelial transitionpentose phosphate pathwayMETMitochondriaHeterogeneityMammalian target of rapamycin complex 1hexokinase 2cyclic adenosine monophosphate response element binding proteinpyruvate kinasevoltage-dependent anion channelfocal adhesion kinaseInterferon gammaepithelial-to-mesenchymal transitionglyceraldehyde-3-phosphate dehydrogenaseReactive oxygen species
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Authors
Pierre Danhier, Piotr BaÅski, Valéry L Payen, Debora Grasso, Luigi Ippolito, Pierre Sonveaux, Paolo E Porporato,