Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5507717 | Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms | 2017 | 11 Pages |
Abstract
Co-expression networks have been shown to be a powerful tool for inferring a gene's function when little is known about it. With the advent of next generation sequencing technologies, the construction and analysis of co-expression networks is now possible in non-model species, including those with agricultural importance. Here, we review fundamental concepts in the construction and application of co-expression networks with a focus on agricultural crops. We survey past and current applications of co-expression network analysis in several agricultural species and provide perspective on important considerations that arise when analyzing network relationships. We conclude with a perspective on future directions and potential challenges of utilizing this powerful approach in crops. This article is part of a Special Issue entitled: Plant Gene Regulatory Mechanisms and Networks, edited by Dr. Erich Grotewold and Dr. Nathan Springer.
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Authors
Robert J. Schaefer, Jean-Michel Michno, Chad L. Myers,