The roles of the Hippo pathway in cancer metastasis

The Hippo pathway is an emerging signaling pathway that plays important roles in development and disease. In cancer cells, dysregulation of the Hippo pathway drives multiple aspects of tumour initiation and progression. Recent studies have uncovered a role for the Hippo pathway core components in promoting cancer metastasis. In this review, we summarize the clinical and biochemical evidence implicating the Hippo pathway in metastasis. Additionally, we describe the molecular mechanisms by which aberrant Hippo signaling promotes metastasis. Finally, we highlight areas for future research.