Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5517854 | International Journal for Parasitology: Drugs and Drug Resistance | 2017 | 7 Pages |
â¢Interactions of tafenoquine with other antimalarials are studied in P. falciparum.â¢Synergistic interactions occur with most drugs in asexual erythrocytic stages.â¢Tafenoquine will likely increase the potency of other drugs against asexual stages.â¢Synergism is found with naphthoquine, pyronaridine and piperaquine in gametocytes.â¢Tafenoquine may interfere with other drugs against P. falciparum gametocytes.
The 8-aminoquinoline tafenoquine (TFQ), a primaquine derivative, is currently in late-stage clinical development for the radical cure of P. vivax. Here drug interactions between TFQ and chloroquine and six artemisinin-combination therapy (ACT) partner drugs in P. falciparum asexual stages and gametocytes were investigated. TFQ was mostly synergistic with the ACT-partner drugs in asexual parasites regardless of genetic backgrounds. However, at fixed ratios of 1:3, 1:1 and 3:1, TFQ only interacted synergistically with naphthoquine, pyronaridine and piperaquine in gametocytes. This study indicated that TFQ and ACT-partner drugs will likely have increased potency against asexual stages of the malaria parasites, whereas some drugs may interfere with each other against the P. falciparum gametocytes.
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