| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5543916 | Research in Veterinary Science | 2017 | 23 Pages |
Abstract
Methotrexate exhibited concentration-dependent inhibitory effect on proliferation of all the examined cell lines with different degree of apoptosis induction. The most methotrexate sensitive cells belonged to CL-1 cell line derived from T cell neoplasia and previously characterized by high resistance to the majority of anticancer drugs used in the therapy of lymphoma/leukemia in dogs. Canine lymphoma and leukemia cell lines are sensitive to methotrexate, and this drug may be useful in effective treatment of canine neoplasms and especially of T-type leukemia/lymphoma.
Related Topics
Life Sciences
Agricultural and Biological Sciences
Animal Science and Zoology
Authors
Aleksandra Pawlak, Justyna Kutkowska, Bożena ObmiÅska-Mrukowicz, Andrzej Rapak,