Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5544941 | The Veterinary Journal | 2016 | 6 Pages |
Abstract
Antibodies against CCS and SOD1 were applicable for use in canine specimens. This was demonstrated by the loss of immune-reactive bands for CCS and SOD1 in siRNA treated canine bile duct epithelial cells. Erythrocyte CCS and CCS/SOD1 ratios were decreased 2.37 (Pâ<0.001) and 3.29 (Pâ<0.001) fold in the high copper group compared to the normal copper group. Erythrocyte CCS and CCS/SOD1 ratio are potential new biomarkers for hepatic copper concentrations in Labrador retrievers and could facilitate early diagnosis and treatment monitoring for copper-associated hepatitis in dogs.
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Authors
K. Dirksen, Y.S. Roelen, M.E. van Wolferen, H.S. Kruitwagen, L.C. Penning, I.A. Burgener, B. Spee, H. Fieten,