Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5544979 | The Veterinary Journal | 2016 | 11 Pages |
Abstract
Vitamin D concentrations show an inverse correlation with incidence of certain tumors in people and dogs. Additionally, human osteosarcoma has been associated with dysregulation of vitamin D-dependent pathways. The study objective was to compare serum 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3 in 20 dogs with osteosarcoma to age- and weight-matched control dogs. We hypothesized that dogs with osteosarcoma would have lower serum 25-hydroxyvitamin D than control dogs. The mean 25-hydroxyvitamin D3 concentrations for dogs with osteosarcoma and matched-controls were 34.95âng/mL and 33.85âng/mL, respectively (Pâ=â0.784). Based on these data, 25-hydroxyvitamin D insufficiency might not be important in the pathogenesis of canine osteosarcoma.
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Authors
Jennifer L. Willcox, Catherine Hammett-Stabler, Marlene L. Hauck,