Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5544993 | The Veterinary Journal | 2017 | 24 Pages |
Abstract
This study investigated whether canine mesenchymal stromal cells (cMSCs) are able to take up and release paclitaxel (PTX) in active form, and therefore whether they have potential as a tool for therapeutic delivery of this drug. cMSCs from bone marrow and adipose tissue were isolated, expanded and characterised phenotypically. cMSCs were loaded with PTX (cMSCs-PTX) and their capacity for release of PTX was determined by their effect on proliferation of cancer cells. cMSCs-PTX derived from bone marrow and adipose tissue were able to take up and then release active PTX. cMSCs-PTC inhibited proliferation of the canine glioma cell line J3T, and the human glioblastoma cell lines T98G and U87MG. The potential of canine cMSCs-PTX for treatment of canine gliomas should be investigated further.
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Authors
A. Bonomi, E. Ghezzi, L. Pascucci, M. Aralla, V. Ceserani, L. Pettinari, V. Coccè, A. Guercio, G. Alessandri, E. Parati, A.T. Brini, O. Zeira, A. Pessina,