Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5545319 | Veterinary Microbiology | 2017 | 7 Pages |
Abstract
Vaccines are useful tools to control influenza A virus infection in poultry, but they need to be periodically reformulated to guarantee appropriate protection from infection and to limit viral replication and circulation, which could favour the emergence of new variants. In this study, a deep sequencing approach was used to characterize and follow the evolution of the hemagglutinin of the H5N1 highly pathogenic avian influenza viral population in infected animals vaccinated with two vaccines conferring different protection levels. Results from this preliminary investigation suggested that the evolution of the viral population, as well as the abundance and heterogeneity of minority variants could be influenced by the immune pressure conferred by vaccination.
Related Topics
Life Sciences
Agricultural and Biological Sciences
Animal Science and Zoology
Authors
Adelaide Milani, Alice Fusaro, Francesco Bonfante, Gianpiero Zamperin, Annalisa Salviato, Marzia Mancin, Eleonora Mastrorilli, Joseph Hughes, Hussein A. Hussein, Magdi Hassan, Egbert Mundt, Calogero Terregino, Giovanni Cattoli, Isabella Monne,