Article ID Journal Published Year Pages File Type
557630 Biomedical Signal Processing and Control 2011 7 Pages PDF
Abstract

The problem of determining an oral dose, or schedule of oral doses, that gives rise to an arbitrary area-under-curve or to points on the time-series for a variable of interest in a drug kinetics model is considered. These two measures are considered as surrogates for the particular drug response to the dose. The approach taken is to formulate the problem as a fixed point one to which a version of the contraction mapping theorem can be applied. The results, illustrated for a model for the anti-cancer agent topotecan, demonstrate the applicability of the approach.

Related Topics
Physical Sciences and Engineering Computer Science Signal Processing
Authors
,