Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
557630 | Biomedical Signal Processing and Control | 2011 | 7 Pages |
Abstract
The problem of determining an oral dose, or schedule of oral doses, that gives rise to an arbitrary area-under-curve or to points on the time-series for a variable of interest in a drug kinetics model is considered. These two measures are considered as surrogates for the particular drug response to the dose. The approach taken is to formulate the problem as a fixed point one to which a version of the contraction mapping theorem can be applied. The results, illustrated for a model for the anti-cancer agent topotecan, demonstrate the applicability of the approach.
Keywords
Related Topics
Physical Sciences and Engineering
Computer Science
Signal Processing
Authors
Neil D. Evans,