Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5588893 | Agri Gene | 2016 | 6 Pages |
Abstract
The maternal recognition of pregnancy in pigs occurs around day 12-13 of gestation. During this period embryo-derived signals act on the endometrium and the myometrium to trigger tissue-specific responses that lead to proper implantation and maintenance of pregnancy. The present study utilized gene expression microarrays to examine embryo-induced alterations in porcine endometrial and myometrial transcriptome on days 12-13 of pregnancy. It has been confirmed that the endometrium and the myometrium, in response to embryonic signals, express unique set of genes. However, a key discovery of this study is the fact that genes that encode crucial factors involved in maternal recognition of pregnancy and preparation of uterus for implantation are regulated similarly in both tissues. Genes responsible for PGs synthesis (PTGES2, PTGR2), uterine development and remodeling (HOXA10, GRB10, MTOR) and innate immune response and immunomodulation (NFKBIA, TRAFD1) were regulated similarly in the endometrium and the myometrium. This suggests that in pigs these tissues act in sync to support embryos during peri-implantation.
Keywords
TNFαPtgs2SMAD4IGF2PGSHOXA10Cy3TLRCy5PGF2αCCR1LHCGRPGE2NOSGrb10NFKBIAODC1mTORGAPDHCEMIL1βEndometriumBLAST, basic local alignment search toolBlastImplantationInterleukin-1βTranscriptometumor necrosis factor αToll-like receptorcorpus luteumPigMicroarrayCyanine 3cyanine 5Actbmyometriumluteinizing hormoneProstaglandin E2Prostaglandin F2αProstaglandins
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Animal Science and Zoology
Authors
B. Wojciechowicz, G. Kotwica, J. KoÅakowska, K. Zglejc, M. Martyniak, A. Franczak,