Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5760430 | Mathematical Biosciences | 2017 | 9 Pages |
Abstract
Simulation results of the proposed model are in conformity with the experimental data recorded from mouse in immunology department of Tehran University of Medical Science as well as what has been explained in the literature. Our results explain dynamics of the immune cells from the first day of cancer growth and progression. Simulation result shows that reducing intervals between immunotherapy injections, efficacy of the treatment will be increased because CD8+ cells are boosted more rapidly. Optimized protocol for immunotherapy suggests that if the effect of DC vaccines on increasing number of anti-tumor immune cells be just before the maximum number of CD8+ cells, the effect of treatment will be maximized.
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Authors
Milad Qomlaqi, Fariba Bahrami, Maryam Ajami, Jamshid Hajati,