Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5762966 | South African Journal of Botany | 2017 | 6 Pages |
Abstract
A. arborescens and C. multicava were not generally active against the tested bacteria. Acetone extracts of A. nilotica bark and T. riparia flower extracts were most active against Gram-positive bacteria. Activity against Gram-negative species, notably Proteus vulgaris and Enterobacter aerogenes, was also recorded with MIC values as low as 0.0195Â mg/ml. The best selectivity index (SI) value of 4.22 was obtained by the T. riparia flower acetone extract against the field strain of Streptococcus uberis. Although a degree of toxicity to mammalian cells was noted in most of the extracts, SI values above 1 indicate that antibacterial activity was greater than cellular toxicity for some extracts, a preliminary indication of safety. These extracts, or purified active compounds derived from them, may prove useful in further investigations of alternative mastitis treatments.
Keywords
PBSATCCLC50SCCMIC3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide50% lethal concentrationMTTSomatic cell countMinimum inhibitory concentrationminimal essential mediumCytotoxicityselectivity indexPhosphate buffered salineAntibacterial activityBovine mastitisMEMAmerican Type Culture CollectionEthnoveterinary medicine
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Authors
P. Sserunkuma, L.J. McGaw, I.V. Nsahlai, J. Van Staden,