Developing transcriptional profiles in Orbicella franksi exposed to copper: Characterizing responses associated with a spectrum of laboratory-controlled environmental conditions

•Cnidarian responses to copper exposure expanded by 52 additional genes.•29 time-dependent responses, 44 concentration-dependent responses.•5 genes responsive to concentration, time, and interactions.•Hormesis is evident in 0.3 ppb treatment.•Cu2+ impacts development, immunity, bulk transport, Ca2+ flux, mitochondria, & ECM.