Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5764265 | Aquatic Toxicology | 2017 | 19 Pages |
Abstract
In our experimental study, we showed that particle uptake in biota is restricted to oral exposure, whereas the dermal route resulted in adsorption to the epidermis and gills only. Ingestion followed by biodistribution was observed for the tested particles of 25 and 50Â nm. The particles spread through the body and eventually accumulated in specific organs and tissues such as the eyes. Particles larger than 50Â nm were predominantly adsorbed onto the intestinal tract and outer epidermis of zebrafish embryos. Embryos exposed to particles via both epidermis and intestine showed highest uptake and eventually accumulated particles in the eye, whereas uptake of particles via the chorion and epidermis resulted in marginal uptake. Organ uptake and internal distribution should be monitored more closely to provide more in depth information of the toxicity of particles.
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Agricultural and Biological Sciences
Aquatic Science
Authors
M. van Pomeren, N.R. Brun, W.J.G.M. Peijnenburg, M.G. Vijver,