Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5794684 | Research in Veterinary Science | 2015 | 7 Pages |
â¢Evaluation of ET-1 and ETAR expression in canine mammary tumours.â¢Increase of expression from benign tumours to G1 and G2 carcinomas.â¢Positive co-localization in benign mammary tumours and in G1 and G2 carcinomas.â¢Decrease of expression and negative co-localization in G3 carcinomas.
Endothelins and their receptors have been implicated in numerous diseases and have recently emerged as relevant players in a variety of malignancies. Tumours overexpress the Endothelin-1 (ET-1) and the Endothelin-A receptors (ETAR) and their interaction enhances tumour growth and metastasis by promoting tumour cell survival, proliferation and angiogenesis. In this study we have evaluated the expression of ET-1 and ETAR in 50 canine mammary tumours, compared to normal controls. Results demonstrated a progressive increase in ET-1 and ETAR expression from benign tumour to grade 1 and to grade 2 malignant mammary tumours with a decrease of expression in grade 3 carcinomas. Co-localization of ET-1 and ETAR was observed in benign mammary tumours and in G1 and G2 carcinomas, while absent in G3 carcinomas. Concluding, ET-1/ETAR can be considered reliable markers for evaluating malignancy of canine mammary tumours and could have importance for the development of specific anticancer therapies.