| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5795197 | Research in Veterinary Science | 2012 | 5 Pages |
Abstract
The influenza A virus genome consists of eight segments of negative-strand RNA. In previous study, we generated a recombinant influenza virus with nine segments by reverse genetics. In present study, we evaluated characteristics of the recombinant influenza virus. The recombinant virus exhibited similar property to wild-type virus on virion morphology, virion composition, plaque phenotype and other aspects. Whereas, the recombinant virus propagated to lower titers than did wild-type virus in cells and mice, and there was decreased protein level and vRNA incorporation in the recombinant virions compared to wild-type H9N2 virions. Our results indicated that influenza A virus with eight segments exhibits more advantages than the virus with nine segments.
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Authors
Rui Wu, Xuke Zhang, Huabin Shao, Qingping Luo, Jun Yang, Diping Xu,