| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5797465 | The Veterinary Journal | 2015 | 7 Pages |
â¢Experimental evidence supports the cancer stem cell model.â¢Lineage tracing and clonal analysis experiments support the clonal evolution and the cancer stem cell models.â¢Drugs that can target cancer stem cells could have clinical benefits.
The existence of subpopulations of cells in cancer with increased tumour-initiating ability, self-renewal potential, and intrinsic resistance to conventional therapeutics formed the basis of the cancer stem cell model. Some tumours have since been viewed as aberrant tissues with a unidirectional hierarchical structure consisting of cancer stem cells at the apex, driving tumour growth, metastasis and relapse after therapy. Here, recent developments in cancer stem cell research are reviewed with a focus on tumour heterogeneity, cellular plasticity and cancer stem cell reprogramming. The impact of these findings on the cancer stem cell model is discussed.
