Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5798861 | The Veterinary Journal | 2012 | 5 Pages |
Abstract
Porcine reproductive and respiratory syndrome virus (PRRSV) is endemic in most parts of Asia, where genotype I and II strains of diverse virulence may coexist. This study evaluated the outcome of infection with a highly virulent Asian genotype II PRRSV isolate in piglets vaccinated with a genotype I vaccine. Twenty-one 3-week-old piglets were divided in three groups: Pigs in group V (n = 8) were vaccinated with an attenuated genotype I commercial PRRSV vaccine, while pigs in group U (n = 8) and a control group (group C; n = 5) were unvaccinated; 6 weeks later, pigs in groups V and U were challenged intranasally with a highly virulent strain of genotype II PRRSV (1 Ã 105 50% tissue culture infectious doses/mL), while pigs in group C received a placebo. Over a period of 21 days after challenge, vaccinated pigs had significantly lower mortality (0/8 versus 2/8), fewer days of fever, a lower frequency of catarrhal bronchopneumonia, higher weight gains (13.4 versus 6.6 kg) and lower levels of viraemia compared to unvaccinated challenged pigs. Immunisation with a genotype I attenuated PRRSV vaccine provided partial protection against challenge with a highly virulent genotype II strain.
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Authors
M. Roca, M. Gimeno, S. Bruguera, J. Segalés, I. DÃaz, I.J. Galindo-Cardiel, E. MartÃnez, L. Darwich, Y. Fang, J. Maldonado, R. March, E. Mateu,