| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5800001 | Veterinary Microbiology | 2015 | 7 Pages |
â¢First report about new emerging PCV2b-1C strains in German domestic pigs.â¢German PCV2b-1C strains show considerable differences in full genome sequences to BDH.â¢Origin of new strains outside of Europe is likely.â¢Diagnostic assays have found to be revalidated.
PCV2 can be divided into three different genotypes: PCV2a, PCV2b and PCV2c. Since 2004/2005 PCV2b has become the predominant genotype in the domestic pig population worldwide. In the years 2010 and 2012 PCV2b mutant strains (mPCV2), classified as PCV2b-1C strains, were detected in porcine circovirus diseases (PCVD) affected pigs in China and the United States, respectively. Within one year (April 2013-April 2014) newly emerging mPCV2 strains were isolated in seven German pig farms routinely vaccinating against PCV2. Histopathological, clinical and molecular biological findings including in-situ hybridization (ISH) and real-time PCR indicate PCVD in the affected animals. Characterized isolates from five farms were closely related to the PCV2b-1C reference strain BDH (GenBank no. HM038017), whereas strains from two other farms were only 99.1% and 99.0% identical (based on the nucleotide sequence of the complete genome) to mPCV2 strain BDH, respectively.
