Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5802061 | Veterinary Parasitology | 2016 | 5 Pages |
â¢The first description of resistance of Teladorsagia circumcincta to moxidectin and ivermectin in sheep in France is reported.â¢Resistance is assessed through the association of classical methods of detection of resistance (FECRT and efficacy test).â¢Pharmacokinetics of moxidectin and ivermectin confirm that parasites were exposed to concentrations lethal for them.
Resistance to ivermectin and moxidectin was explored by a faecal egg count reduction test in two sheep flocks with suspected anthelmintic resistance. The FECRT confirmed one suspicion, with a mean percentage of reduction in egg excretion within the treated groups of 0% for ivermectin (CI 95%: â228 to 58) and 13% for moxidectin (CI 95%: â152 to 70). This was further explored by a controlled efficacy test. An experimental infection of 18 naïve lambs was set up using infective larvae isolated from this flock (5000 L3/lamb). Compared to the control group, abomasal worm burdens (Teladorsagia circumcincta) were reduced by 90% [CI 95%: 81.5-94.8] and 85% [CI 95%: 72.4-92.2] after ivermectin (p < 0.05) and moxidectin (p < 0.05) treatment respectively. Again, compared to the control group, there was a reduction for intestinal strongyles (Trichostrongylus colubriformis) of 100% and 99% [CI 95%: 97.5-99.7] for ivermectin and moxidectin respectively. No difference was found between the efficacy of moxidectin and ivermectin. Pharmacokinetic values indicated that the strongyles were submitted to anthelmintic concentrations usually lethal to them. This trial demonstrated the first multiple resistance of ovine strongyles in France.