Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5817092 | Experimental and Toxicologic Pathology | 2015 | 5 Pages |
Abstract
Histopathological analyses of the exposed cultures showed a reduction of cilia bearing cells, shortening of existing cilia and finally disappearance of all cilia in cigarette smoke exposed cells. In cultures exposed to charcoal filtered cigarette smoke, little changes in cilia length were seen after four exposure repetitions, but those effects were reversed after a two day recovery period. Those differences indicate that volatile organic compounds, being removed by the charcoal filter tip, affect primary bronchiolar epithelial cells concerning their cilia formation and function comparable with the in vivo situation. In conclusion, our in vitro model presents a valuable tool to study air-borne ciliatoxic compounds.
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Authors
Michaela Aufderheide, Stefanie Scheffler, Shigeaki Ito, Shinkichi Ishikawa, Makito Emura,