Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5817182 | Experimental and Toxicologic Pathology | 2013 | 9 Pages |
Abstract
Arc/Arg3.1 and Rac1 genes, and their protein products were selected for further examination. Arc was elevated upon two-week to three-month exposure to coarse PM and declined after 10-month exposure. Rac1 was significantly elevated upon 10-month coarse PM exposure. On human brain tumor sections, Arc was expressed in benign meningiomas and low-grade gliomas but was much lower in high-grade tumors. Conversely, Rac1 was elevated in high-grade vs. low-grade gliomas. Arc is thus associated with early brain changes and low-grade tumors, whereas Rac1 is associated with long-term PM exposure and highly aggressive tumors. In summary, exposure to air PM leads to distinct changes in rodent brain gene expression similar to those observed in human brain tumors.
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Authors
Julia Y. Ljubimova, Michael T. Kleinman, Natalya M. Karabalin, Satoshi Inoue, Bindu Konda, Pallavi Gangalum, Janet L. Markman, Alexander V. Ljubimov, Keith L. Black,