| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5908946 | Infection, Genetics and Evolution | 2015 | 26 Pages |
Abstract
Streptococcus pyogenes (group A Streptococcus; GAS) is a strict human pathogen with a very high prevalence worldwide. This review highlights the genetic organization of the species and the important ecological considerations that impact its evolution. Recent advances are presented on the topics of molecular epidemiology, population biology, molecular basis for genetic change, genome structure and genetic flux, phylogenomics and closely related streptococcal species, and the long- and short-term evolution of GAS. The application of whole genome sequence data to addressing key biological questions is discussed.
Keywords
HGTMLSTGCsMMRURTMSCRAMMsC4bpSLVSOFLCBCGHGGSStreptococcus dysgalactiae subspecies equisimilisMicrobial surface components recognizing adhesive matrix moleculesGroup G streptococciGroup C streptococciStreptococcus equi subspecies zooepidemicusSmall regulatory RNAFnBPNAD+-glycohydrolaseCRISPRAGRSPESDDdeoxyribonucleaseGBSSDACASEMMMGESDEDNAseStreptococcus pyogenesGroup B streptococciHorizontal gene transferEpidemiologyStreptococcal pyrogenic exotoxinMultilocus sequence typingcomparative genomic hybridizationmismatch repairGenetic diversityUpper respiratory tractSubfamilyPopulation biologySRNAMobile genetic elementIntegrative and conjugative elementEvolutionClonal complexSequence typeHaplotypeC4b-binding proteinFibronectin-binding proteinGenomicsGasGroup A streptococciGroup A StreptococcusIce
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Authors
Debra E. Bessen, W. Michael McShan, Scott V. Nguyen, Amol Shetty, Sonia Agrawal, Hervé Tettelin,