| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5908961 | Infection, Genetics and Evolution | 2015 | 8 Pages |
Abstract
We propose that viral diversity generated during HPVs chronic infection may be fueled by innate and adaptive immune pressures. Further research will be needed to understand the dynamics of viral DNA variability, differentially in benign and malignant lesions, as well as in tissues with differential intensity of immune surveillance. Finally, the impact of intralesion viral diversity on the long-term oncogenic potential may deserve closer attention.
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Authors
Cristina Mendes de Oliveira, Ignacio G. Bravo, Nathália Caroline Santiago e Souza, Maria Luiza Nogueira Dias Genta, José Humberto Tavares Guerreiro Fregnani, Maricy Tacla, Jesus Paula Carvalho, Adhemar Longatto-Filho, José Eduardo Levi,