Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5909799 | Infection, Genetics and Evolution | 2014 | 10 Pages |
Abstract
The carbapenemase genes blaKPC-2, blaKPC-3, and blaVIM-4 were identified in carbapenem-resistant and intermediate susceptible isolates, blaOXA-72 in an extended-spectrum β-lactamase (ESBL)-positive one. Furthermore, the observed high prevalence of the acquired blaDHA-1 and blaCMY AmpC β-lactamase genes (70%) in phenotypically AmpC-positive isolates is alarming due to their capability to become carbapenem-resistant upon changes in membrane permeability. The statistical analyses revealed that approximately 55% of all β-lactamase genes present in the General Hospital Vienna were detected by this study. In summary, this work gives a very detailed picture on the disseminated β-lactamases and other resistance genes in one of Europe's largest hospitals.
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Authors
Ivan BariÅ¡iÄ, Dieter Mitteregger, Alexander M. Hirschl, Christa Noehammer, Herbert Wiesinger-Mayr,