Article ID Journal Published Year Pages File Type
5909820 Infection, Genetics and Evolution 2014 6 Pages PDF
Abstract

•Genomic analyses of a rotavirus G8P[1] provides evidence of animal-to-human transmission.•Analyses reinforce the notion of signature NSP4 genotype for ungulates from South America.•Surveillance in humans and animals will help in understanding rotavirus epidemiology.

Group A rotavirus is a major cause of severe gastroenteritis in children and young animals. During a retrospective analysis of samples collected from Paraguayan children under 5 years old with diarrhea, and previously negative for rotavirus and norovirus, we detected the presence of bovine rotavirus sequences by viral metagenomics. Nucleic acid was extracted direct from stool sample and determined to be G8P[1]. The genomic analyzes revealed that the strain presents an Artiodactyl-like genome (G8-P[1]-I2-R2-C2-M1-Ax-N2-T6-E12-H3) suggesting a direct animal-to-human transmission.

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