| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5910747 | Infection, Genetics and Evolution | 2013 | 6 Pages |
Abstract
NLRP1 might be involved in the susceptibility to leprosy with particular emphasis for PB clinical form. Although preliminary, this is the first report linking NLRPs and inflammasome with leprosy: replication studies as well as functional assays are envisaged to deeper investigate the role of NLRP1 in M. leprae infection. Interestingly, NLRP1 SNPs were previously associated to susceptibility to Crohn disease, suggesting that NLRP1 could be a new modifier gene in common between leprosy and Crohn disease.
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Authors
Alessandra Pontillo, Weber Laurentino, Sergio Crovella, Ana Carla Pereira,