| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5910949 | Infection, Genetics and Evolution | 2013 | 7 Pages |
Abstract
- Rodent malaria parasites (Plasmodium chabaudi) resistant to artesunate (ATN)Â +Â mefloquine (MF) were previously selected.
- ATNÂ +Â MF-resistant parasites were shown to attain amplification of the mdr1 gene after the evolution of resistance.
- Here, the blood-stage fitness associated with artesunate + mefloquine (ATN + MF) resistance was investigated in vivo.
- There was no fitness cost linked to ATNÂ +Â MF resistance, and consequently, to mdr1 amplification.
- The improved growth of the ATNÂ +Â MF-resistant parasites may be due to selection of compensatory mutations.
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Authors
Louise Rodrigues, Gisela Henriques, Pedro Cravo,