Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5911082 | Infection, Genetics and Evolution | 2013 | 11 Pages |
â¢We documented the first evidence of recombination between DENV-3 viruses.â¢Two viruses represent recombination between viruses from different genotypes.â¢We identified multiple breakpoints sites in the recombinant viruses.â¢Multiple strand switching may be linked with the genomic mosaicism.
Recombination is a significant factor driving genomic evolution, but it is not well understood in Dengue virus. We used phylogenetic methods to search for recombination in 636 Dengue virus type 3 (DENV-3) genomes and unveiled complex recombination patterns in two strains, which appear to be the outcome of recombination between genotype II and genotype I parental DENV-3 lineages. Our findings of genomic mosaic structures suggest that strand switching during RNA synthesis may be involved in the generation of genetic diversity in dengue viruses.