| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5911396 | Infection, Genetics and Evolution | 2012 | 7 Pages |
Abstract
⺠We analyzed the role of membrane cholesterol and low vacuolar pH in CHIKV infection of mosquito cells. ⺠We tested the influence of the E1-A226V mutation detected in reemerging CHIKV on these parameters. ⺠Infection of mosquito cells is sensitive to lysomotropic agents and requires membrane cholesterol. ⺠The E1-226V mutation is associated with an increased fitness for A. albopictus cells. ⺠This mutation confers an increased requirement for membrane cholesterol and for low endosomal pH.
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Authors
Bernard Gay, Eric Bernard, Maxime Solignat, Nathalie Chazal, Christian Devaux, Laurence Briant,