| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5911460 | Infection, Genetics and Evolution | 2012 | 14 Pages |
Abstract
⺠We review the population structure of Trypanosoma cruzi, causative agent of Chagas disease. ⺠We provide information on the eco-epidemiology of T. cruzi discrete typing units (DTUs). ⺠We outline the correlation of DTU with clinical manifestations. ⺠We summarize methods for DTU genotyping. ⺠Understanding of T. cruzi genetic diversity will provide new insights to future interventions.
Keywords
Trypanosoma cruzi strainsSNPsRAPDRFLPMLSTNTSRandomly amplified polymorphic DNAMultilocus enzyme electrophoresisMultilocus sequence typingGenotypingMLEEspliced leadernon-transcribed spacerPhylogeographyHybridizationDiscrete typing unitPathologyrestriction fragment length polymorphismSingle-nucleotide polymorphisms
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Authors
Bianca Zingales, Michael A. Miles, David A. Campbell, Michel Tibayrenc, Andrea M. Macedo, Marta M.G. Teixeira, Alejandro G. Schijman, Martin S. Llewellyn, Eliane Lages-Silva, Carlos R. Machado, Sonia G. Andrade, Nancy R. Sturm,