Article ID Journal Published Year Pages File Type
5911479 Infection, Genetics and Evolution 2012 6 Pages PDF
Abstract
► Evolutionary rates are statistically identical in all DENV serotypes. ► The E gene codon sites are under strong purifying selection. ► No evidence of adaptive molecular evolution was found on the basal branches of DENV. ► DENV genetic diversity presents a strong geographic structure on a global scale. ► Effective population sizes of DENV-1, 2 and 3 have increased since the early 2000s.
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