| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5921956 | Journal of Insect Physiology | 2012 | 6 Pages |
Abstract
⺠Triterpenoid and steroid saponins have strong cytotoxic effects on Drosophila S2 cells. ⺠These cytotoxic effects can be explained by rapid permeation of the insect cell membrane. ⺠We found no true agonistic or antagonistic activity on the EcR-receptor. ⺠Lower saponin concentrations induce apoptosis with DNA fragmentation. ⺠The saponin effects were counteracted by cholesterol.
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Authors
Ellen De Geyter, Luc Swevers, Thomas Soin, Danny Geelen, Guy Smagghe,