Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6370070 | Journal of Theoretical Biology | 2015 | 14 Pages |
Abstract
â¢A mathematical model of bacterial nucleotide excision repair system is developed.â¢A whole sequence of UV-induced mutagenesis in repair-deficient cells is modelled.â¢Error-prone DNA repair is about four times more efficient than error-free repair.â¢Temporal modulation of SOS-inducing signal is predicted.
A model of the UV-induced mutation process in Escherichia coli bacteria has been developed taking into account the whole sequence of molecular events starting from initial photo-damage and finishing with the fixation of point mutations. The wild-type phenotype bacterial cells are compared with UV-sensitive repair-deficient mutant cells. Attention is mainly paid to excision repair system functioning as regards induced mutagenesis.
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Authors
Aleksandr N. Bugay, Evgeny A. Krasavin, Aleksandr Yu. Parkhomenko, Maria A. Vasilyeva,