Article ID Journal Published Year Pages File Type
6371109 Journal of Theoretical Biology 2012 7 Pages PDF
Abstract
► DNA methylation is perturbed in myelodysplasia and leukemia. ► We model DNA methylation using a dynamic multicompartmental approach. ► Levels of methylation depend on enzymatic activity of Dnmt and Tet family proteins. ► Predicted methylation levels are consistent with published experimental data. ► Increased Tet activity maintains hypomethylation at CpG islands.
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Life Sciences Agricultural and Biological Sciences Agricultural and Biological Sciences (General)
Preview
A dynamic multi-compartmental model of DNA methylation with demonstrable predictive value in hematological malignancies
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