Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6371165 | Journal of Theoretical Biology | 2012 | 12 Pages |
Abstract
⺠This is a computational study of interactions between calcium homeostasis and mechanical stimulation at the level of a single osteocyte. ⺠Hydraulic pressure governs the canalicular fluid flow. ⺠Calcium fluxes generate osmotic currents near the canalicular walls and the cell membrane. ⺠Shear stress experienced by osteocytes is affected by mechanical loading and by disbalance in calcium homeostasis. ⺠Calcium homeostasis state (such as osteopenia) may affect bone responsiveness to mechanical forces.
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Authors
J. Kaiser, T. Lemaire, S. Naili, V. Sansalone, S.V. Komarova,